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T0389 |
Dabigatran etexilate
|
BIBR 1048 |
Thrombin
|
|
Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. |
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T5133 |
Dabigatran Etexilate Mesylate
|
BIBR 1048MS,Dabigatran etexilate methanesulfonate |
Thrombin
|
|
Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM). |
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T26689 |
AVE-0118
|
AVE 0118,AVE0118 |
Potassium Channel
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AVE-0118 is a potassium channel blocker and suppresses persistent atrial fibrillation. |
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T68038 |
Celivarone
|
|
Potassium Channel
|
|
Celivarone is a potassium channel blocker used in the study of arrhythmias, atrial flutter and atrial fibrillation. |
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T30520 |
BMS-394136
|
BMS394136,BMS 394136,BMS394136;UNII-M694U7167K |
Potassium Channel
|
|
BMS-394136 (BMS 394136) is a KV1.5 antagonist for the treatment of cardiovascular diseases such as arrhythmias and atrial fibrillation. |
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T1073 |
Dronedarone hydrochloride
|
Dronedarone HCl,SR33589 |
Potassium Channel
,
Calcium Channel
,
Sodium Channel
,
Adrenergic Receptor
,
Autophagy
|
|
Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation. |
|
T28748 |
Selodenoson
|
RG14202,DTI0009,DTI-0009,RG-14202,DT-009,DT009 |
Adenosine Receptor
|
|
Selodenoson (RG-14202) is a selective adenosine A1 receptor agonist used to slow the heart rate in patients with atrial fibrillation and to treat arrhythmias. |
|
T30544 |
BMS-919373
|
BMS919373,BMS 919373 |
Potassium Channel
|
|
BMS-919373 is a potassium channel Kv1.5 (KCNA5) inhibitor for atrial fibrillation and acute coronary syndrome. |
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T68730 |
AVE1231
|
|
Potassium Channel
|
|
AVE1231 is a TASK-1 channel blocker that inhibits TASK-1 and can be used in the study of atrial fibrillation. |
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T13021 |
Sulamserod
|
RS-100302 |
5-HT Receptor
|
|
|
|
T61913 |
Cavutilide
|
|
EGFR
|
|
Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation. |
|
T83979 |
Sulcardine 2HCl
|
Sulcardine 2HCl（343935-60-4 Free base）,HBI-3000 2HCl |
HER
,
Sodium Channel
|
|
Sulcardine 2HCl is a multi-ion channel blocker with antiarrhythmic effects that blocks the properties of hERG and hNav1.5 channels and can be used to study atrial fibrillation and ventricular arrhythmias. |
|
T6295 |
Dabigatran
|
BIBR 953,BIBR 953ZW |
Thrombin
|
|
Dabigatran (BIBR 953ZW) is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients... |
|
T6476 |
Dofetilide
|
UK 68789,UK-68798,Tikosyn |
Potassium Channel
|
|
Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ik... |
|
T0815L |
Warfarin sodium
|
|
|
|
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, an... |
|
T30678 |
C1-resveratrol
|
C1resveratrol,C1 resveratrol |
|
|
C1 resveratrol is a novel multifunctional derivative of resveratrol, which is used to treat atrial fibrillation. |
|
T68893 |
Vanoxerine free base
|
|
|
|
Vanoxerine, also known as GBR-12909; I-893, is a dopamine ruptake inhibitor potentially for the treatment of atrial fibrillation. |
|
T30607 |
Budiodarone
|
ATI2042,ATI-2042,ATI 2042 |
|
|
Budiodarone（ATI-2042）is a chemical analog of an antiarrhythmic drug and amiodarone. Budedalone is promising as an antiarrhythmic agent for the prevention of atrial fibrillation. |
|
T37821 |
AP 14145 hydrochloride
|
|
|
|
KCa2 (small conductance Ca2+-activated potassium) channel negative allosteric modulator (IC50 = 1.1 μM). Increases the EC50 of Ca2+ on KCa2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rat... |
|
T21373 |
Aprindine hydrochloride
|
Fiboran,Amidonal,Aprinidine,Aprindin,Aprindine HCl,Aprindina,Fibocil |
|
|
Aprindine HCl is a Class 1b antiarrhythmic agent used to manage ventricular and supraventricular arrhythmias. In one study, it delayed atrial fibrillation more than digoxin did. It has shown effectiveness when given oral... |
|
T21391 |
Flecainide
|
Tambocor,Apocard,Flecainida,Flecainidum |
|
|
Flecainide acetate is a class Ic antiarrhythmic agent, it is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation, paroxysmal supraventricular tachycardia, and ventricular tachycardia. ... |
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T62283 |
DDO-02005
|
|
|
|
DDO-02005 is a potent inhibitor of the Kv1.5 calcium channel (IC50: 0.72 μM).DDO-02005 exhibits good anti-fibrillation effects in a CaCl2-ACh atrial fibrillation rat model and is effective against anti-aconitine-induced ... |
|
T39963 |
AP14145 hydrochloride
|
|
|
|
AP14145 hydrochloride is a potent negative allosteric modulator of K Ca 2 (SK) channels, specifically targeting K Ca 2.2 (SK2) and K Ca 2.3 (SK3) channels with an IC 50 of 1.1 μM. Inhibition of AP14145 hydrochloride is h... |
|
T62207 |
KVI-020
|
|
|
|
KVI-020 is a selective, orally active blocker of the atrial potassium channel Kv1.5 (IC50: 480 nM). kVI-020 exhibits inhibition of hERG (IC50: 15100 nM). KVI-020 is a potent antiarrhythmic agent and can be used in the st... |
|
T30192 |
Atecegatran metoxil
|
Atecegatran fexenetil,AZD-0837,AZD 0837,AZD0837 |
|
|
Atecegatran Metoxil (Atecegatran Fexenetil ,AZD0837) is an oral direct thrombin inhibitor,which currently in clinical development for the prevention of stroke and systemic embolic events in patients with atrial fibrillat... |
|
T79195 |
Cav 3.2 inhibitor 4
|
|
Calcium Channel
|
|
Cav 3.2 Inhibitor 4 (Compound 21) is a selective and potent inhibitor of the T-type calcium channel (Ca v 3.2), demonstrating peripheral restriction with an IC50 value of 0.6 μM. It is utilized in atrial fibrillation res... |
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T80039 |
ATX-II
|
|
Sodium Channel
|
|
ATX-II, an Na+ channel modulator toxin derived from the sea anemone (Anemonia sulcata), causes delayed inactivation of the Na+ channels and has been linked to pulmonary vein arrhythmogenesis and atrial fibrillation [1] [... |
|
T61231 |
DDO-02005 free base
|
|
|
|
DDO-02005 (free base), a potent Kv1.5 potassium channel inhibitor, demonstrates an IC 50 of 0.72 μM. It exhibits effective anti-atrial fibrillation (AF) properties in the CaCl2-ACh AF rat model and anti-arrhythmic activi... |
|
T82936 |
ATX-II TFA
|
|
Sodium Channel
|
|
ATX-II TFA, a specific Na+ channel modulator toxin, is derived from the venom of the sea anemone (Anemonia sulcata). This compound impedes the inactivation of Na+ channels and has been associated with arrhythmogenesis in... |
|
TMIH-0173 |
Dabigatran-d4 HCl
|
|
|
|
Dabigatran-d4 HCl is a deuterated compound of Dabigatran HCl. Dabigatran HCl has a CAS number of 211914-51-1. Dabigatran is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention... |
|
T64099 |
FXIa-IN-9
|
|
|
|
FXIa-IN-9 (compound 3f) is a potent, selective inhibitor of FXIa, demonstrating strong binding affinity through hydrogen bond formation (human FXIa K i : 0.17 nM, rabbit FXIa K i : 0.5 nM). It exhibits anticoagulant prop... |
